Predictors of Survival among Patients under Multi-drug Resistant Tuberculosis Treatment in Ogun State Treatment Center, Nigeria

Abstract

Background: Drug-resistant Tuberculosis (TB) threatens global TB care and prevention, and it remains a major public health concern in many countries including Nigeria. Ending this pandemic requires understanding factors that influence mortality most especially during the interim phase of treatment. This study assessed the predictors of survival among patients under multi-drug resistant tuberculosis treatment in Ogun State treatment center, Nigeria. Methods: A retrospective study was conducted among patients who are resistant to rifampicin and referred to Sacred Heart Hospital Lantoro Abeokuta Ogun State, Complete information from two hundred and seventy-nine clients was extracted from existing record via a proforma entered into statistical software (SPSS version 23) after correction for errors.  Descriptive and inferential statistics were done with the appropriate test statistic. P value ≤ 0.05 was considered statistically significant. Results: Respondents with the highest frequency were the age group 20-40 years (56%), male (63.4%), and married (62.4%). Baseline Clinical data had treatment after failure (26.9%), HIV positive (12.9%), blood sugar level above 126mg/dl (2.9%), PCV less than 30mg/dl (17.6%) while those with deranged liver function test (28%). Four months after starting treatment, the majority (91.8%) were alive while (8.2%) had died. The likelihood of survival is higher among ever-married (OR= 1.3, 95% CI= 1.5 – 1.7) and lower among retreatment cases (OR= 0.5, 95% CI= 4.5 – 6.5). Conclusion: This study revealed that clients' marital status and categorization of cases influence interim survival after 4 months of treatment with drug-resistant tuberculosis.